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Morerecently, through meticulous research in ani-mals and humans, this has changed, and it is nowrecognised that even preterm infants are suf? -ciently mature to perceive and respond to pain-ful stimuli. Manuscripts that dealwith the nature, assessment, prevention, and treatment of communication disorders areinvited. Inflammatory markers and the metabolicsyndrome insights from therapeutic interventions. Ginkgo is believed to decrease platelet aggrega-bility (clumping) and fibrinogen

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Originally developed to facilitate the framing of questions in evidence-basedmedicine, the PICO template is now widely used by many health care professionals(Dollaghan, 2007; Falzon, Davidson, & Bruns, 2010; Richardson, Wilson, Nishikawa, &Hayward, 1995; Wong & Hickson, 2011).

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